Words similar to steroidogenesis
Example sentences for: steroidogenesis
How can you use “steroidogenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
Overall, these data are consistent with previous reports that endocrine cells express voltage-sensitive ion channels that can contribute to the regulation of not only resting membrane potential and cell volume, but also cell proliferation and steroidogenesis [ 12 13 16 18 21 28 29 30 31 32 33 34 35 36 37 ] . The K +currents blocked by 4-AP in pig GC are conducted by ion channels formed by heteromeric complexes of pore-forming subunits from the KCNA (also called Kv1 or Shaker) family of proteins and accessory subunits from the KCNAB (also called Kvβ) family of proteins [ 4 ] . Similar 4-AP-sensitive K +currents play a key role in transduction of mitogenic signals in a variety of cell types, and 4-AP treatment has been associated with not only growth arrest but also apoptosis [ 2 3 8 9 10 14 38 39 40 41 42 ] .
In our experiments, the chloride influx and membrane hyperpolarization associated with 4-AP treatment not only decreased expression of StAR, but also inhibited cAMP production and steroidogenesis.
Hormonal signal transduction and steroidogenesis can be affected by changes in intracellular and extracellular concentrations of inorganic ions, cellular resting membrane potential, and cell size [ 29 30 35 54 55 56 57 58 59 ] . Blockade of 4-AP sensitive K +channels in non-nerve, non-muscle cells can lead to changes in transmembrane ion gradients, membrane potential and cell volume [ 42 60 ] . On this basis, we determined the effects of 24 h exposure to 4-AP on GC size, membrane potential and intracellular potassium ([K +] in ).
These collective findings may point the way toward further investigations into the role of metabolic variability in steroidogenesis and metabolism in relation to breast cancer risk, and target women who may be most at risk for the disease.
Chloride channels or chloride ions are known to influence cAMP-stimulated steroidogenesis by adrenal cells [ 29 ] , human chorionic gonadotropin (hCG)-stimulated steroidogenesis by amphibian follicle-enclosed oocytes [ 56 ] , as well as LH-stimulated steroidogenesis in rat Leydig cells [ 29 ] , MA-10 cells [ 59 ] , and chicken GC [ 35 ] . In mammalian cells, removal of extracellular chloride stimulates basal and protein kinase A (PKA)-dependent steroid hormone production by increasing the expression of StAR and potentiating the effects of submaximal concentrations of cAMP [ 29 59 ] . The proposed mechanism of action involves chloride efflux, depolarization of the mitochondrial and plasma membranes, and alterations to protein synthesis and cholesterol transport [ 29 59 ] .
Loading...