Words similar to steroid-responsive

Example sentences for: steroid-responsive

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Mutations in MYOC have been shown to be causative for primary open angle glaucoma (POAG) [ 1 2 3 ] . Glucocorticoids have been implicated in ocular hypertension and glaucoma due to increased plasma cortisol levels [ 4 5 ] and altered cortisol metabolism [ 6 7 ] in POAG patients and from the increased risk of developing POAG in steroid-responsive patients [ 8 9 ] . Myocilin has been shown to be upregulated in glucocorticoid-treated human trabecular meshwork (TM) cells [ 10 11 ] , and there is variable evidence for increased MYOC expression in glaucomatous individuals [ 12 13 14 ] . In addition, glaucoma patients have a higher chance of responding to steroids than non-glaucomatous individuals.
Enhancement of IL-6 production by dexamethasone treatment has been previously observed in Kaposi's sarcoma cells [ 32 ] . In the case of NRP-154 cells, the steroid-responsive element for dexamethasone on the IL-6 promoter may have been mutated to a form that does not bind steroid receptors.
There the GR acts as a ligand-activated transcriptional stimulator or repressor of primary response genes by binding to glucocorticoid hormone-responsive elements (GRE) contained in the promoter regions of steroid-responsive genes and either facilitating or repressing the formation of an active transcriptional complex.