Words similar to pten

Example sentences for: pten

How can you use “pten” in a sentence? Here are some example sentences to help you improve your vocabulary:

Restoring PTEN protein or function to reduce PI-3Kinase signaling prevents tumor growth in animal models.
Second, MADS-IX and PTEN were screened in four breast tumor cell lines (HCC-1806, HCC-1143, HCC-1428 and HCC-1937) and matched normal DNA.
Seven tumors had lost the wild type Pten allele (see Fig.
In light of the well-established growth-inhibitory effects exerted by increased levels of this phosphatase, it is reasonable to conclude that this activation of PTEN significantly contributes to the anchorage-dependent phenotype, i.e., to the inhibition of cell proliferation after detachment from matrix.
It should be noted that the fibroblast cells lines we used remain fully viable after detachment and transfer to suspension culture [ 31 43 ] . This is in contrast to most epithelial cells which undergo anoikis, i.e., apoptotic cell death after the disruption of cell-matrix interactions [ 45 ] . It is of interest that some anchorage-independent tumor cells, most of which are of epitheloid origin, become susceptible to anoikis after the introduction of exogenous PTEN [ 23 34 35 36 ] . These observations are in line with the established ability of PTEN to down-regulate the phosphatidylinositol 3-kinase (PI3-K)/PKB survival pathway [ 11 46 ] . The absence of anoikis in our two cell lines may reflect inherent cell type specific differences, i.e., the superior ability of fibroblasts to survive under suspension culture conditions.