Words similar to pten
Example sentences for: pten
How can you use “pten” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, it may not be possible to restore PTEN in human tumors.
First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.
As shown in Figure 6, the degree of PTEN induction was essentially the same in the absence or presence of p53, indicating that p53 did not affect the induction of PTEN protein under these conditions.
Additional growth-inhibitory effects of increased PTEN activity are likely to occur through the stimulation of the cell cycle inhibitor p27 Kip1.
In order to determine the relative increase in PTEN mRNA levels, the Northern blots were stripped and re-hybridized with control probes for β-actin and choA, the latter a highly abundant mRNA of unknown function [ 40 ] . We consistently found that the amount of β-actin mRNA was somewhat reduced during suspension culture, whereas the amount of choA remained relatively stable.
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