Words similar to pten

Example sentences for: pten

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Therefore, it is possible that the signal pathway controlled by Pten is one of the preferred partners of the Wnt-1 pathway in cancer progression, although it remains possible that LOH at the Pten locus is more likely to occur than for the other alleles crossed into Wnt- 1 TG mice.
Previous studies by others had shown that the ectopic expression of PTEN in anchorage-independent tumor cells greatly reduced their ability to grow in soft agar [ 4 5 6 ] . In this latter situation, however, the forced expression of ectopic PTEN effectively impairs cellular proliferation in general, even under two-dimensional culture conditions where the cells are attached to substratum [ 4 6 7 8 9 10 18 33 44 ] . It was therefore difficult to discern from these experiments how effectively and selectively PTEN participates in anchorage-dependent growth control.
This glioma is deficient in PTEN and shows constitutive activation of Akt, which can be inactivated by re-introduction of PTEN [ 47 ] .
Here, we present our findings that in normal anchorage-dependent fibroblast cells, the expression and activity of endogenous PTEN is increased when cellular adhesion to matrix is disrupted.
R-CW cultured the cells and performed the expression analysis of PTEN.