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Example sentences for: ptgs
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Here we report that the Arabidopsis C73 and C97 trans-silencer loci displayed TGS and trans-silencing after first passing through a transitory phase of PTGS over the course of the first two transgenic generations.
The RDRP is a component of the PTGS system that has been initially described in plants as a cellular RNA polymerase activity induced upon viral infection that synthesized antisense RNA in a primer-dependent or independent manner [ 26 47 48 49 50 ] . Subsequent genetic studies showed that mutations in RDRP genes impaired PTGS in a variety of systems [ 25 38 51 52 ] . Experimental studies in C. elegans and in plants suggested that the RDRP is involved in production and amplification of dsRNA using the target RNA as template and siRNAs as primers or guides and resulting in amplification of the RNA silencing response [ 53 54 55 56 ] .
RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), is now recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in essentially all eukaryotes [ 16 ] . Recently, the technique has been successfully applied to cultured mammalian cells, whereby introduction of 21-nucleotide long synthetic dsRNA molecules corresponding to specific mRNA sequences effectively and specifically degraded the cognate mRNAs and abrogated the expression of the corresponding proteins [ 17 18 ] . This prompted us to test a similar approach to knockdown PfPP1 function in the erythrocytic P. falciparum stages.
The phenomenon of RNAi (or PTGS) is of great interest for two reasons [ 9, 10, 11, 12].
This dosage dependence of endogene silencing was the same as for the PTGS locus E82 (Fig.
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