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Example sentences for: pth

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We have recently reported the anabolic action of PTH in an ovariectomized (OVX) Swiss-Webster mouse model, which like the rat model, displays a substantial amount of trabecular bone in its femoral metaphyses and a quantifiable loss of bone following OVX [ 11 ] . The aim of this study was to investigate the effect of simvastatin on the microarchitecture of bone in an established mouse model of osteoporosis, and compare its anabolic action with PTH.
A total sample size of 72 animals (n = 9 per treatment condition) was required to provide 90% power (α = 0.05, β = 0.1) to detect a significant difference of 1 standard deviation (effect size = 1.0) between the Simvastatin, PTH, OVX, and SHAM treatments with respect to each trabecular and cortical bone parameter using one-way analysis of variance (ANOVA) with a two-tailed significance level of 0.05.
PTH treated mice, however revealed an increase (596 ± 138 ng/ml) over T13/OVX/VEH animals (252 ± 57 ng/ml, P < 0.001, Figure 2).
While PTH demonstrated the expected anabolic effect on bone, SVS failed to stimulate bone formation, despite our verification by LC/MS of the active SVS-OH metabolite in mouse serum.
Although the difference in serum PTH levels between patients with HIVAN and patients with other causes of renal disease appeared large, it was not significant in Mann-Whitney testing (p = 0.34) or t-tests of logarithmically transformed values of serum PTH (p = 0.64).