Words similar to pten-deficient

Example sentences for: pten-deficient

How can you use “pten-deficient” in a sentence? Here are some example sentences to help you improve your vocabulary:

These results confirm that inhibition of IGF-I signaling by an inhibitory antibody can suppress growth of a PTEN-deficient glioma cell line.
To test initially whether the PTEN-deficient U87 glioma cells might be susceptible to inhibition of the IGF-IR, we measured colony formation and tumor growth in the presence of an inhibitory antibody to the human IGF-IR (αIR3).
Because essentially all of these previous studies have analyzed PTEN function by introducing the cloned version of the gene back into PTEN-deficient cells, essentially nothing is known about the regulation of the endogenous PTEN gene in response to alterations of cell-matrix interactions.
The results obtained with the dominant negative IGF-IR are identical to published results reintroducing PTEN, hence, inhibition of upstream PI-3Kinase signaling might be a useful approach for PTEN-deficient tumors.
The PI-3Kinase-dependent activation of Akt is thought to play a central role in the cell survival pathway in many cells [ 7 19 20 ] . Elevated Akt activity and protein is found in many PTEN-deficient cancer cells.