Words similar to pthrp

Example sentences for: pthrp

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The smad7 gene contains a perfect palindromic Smad binding element (GTCTAGAC) while the pai-1 and the pthrp promoters harbor AGAC tandem repeats [ 19 33 ] which binds Smad proteins less efficiently [ 34 ] . The upa gene contains only an AP1-binding site which resembles the Smad3/4-responsive AGAC motif [ 35 ] . A weaker binding site could require Smad3 to be present at higher concentrations for efficient binding and would make TGFβ-dependent transcription from a gene more vulnerable to reduced nuclear accumulation of the Smad3 protein.
The strongest effect of SB-203580 was found on the TGFβ-dependent expression of pthrp and upa . In these cases, the inhibitor completely eliminated responsiveness to TGFβ.
TGFβ induced pai-1 mRNA was reduced to approximately 50% by the SB inhibitor, whereas TGFβ-mediated expression of PTHrP and uPA was highly sensitive to SB-203580 treatment.
It is clear that the smad7 gene expression is regulated by TGFβ in a Smad3/4-dependent manner [ 32 ] as it was found for the pthrp and the pai-1 gene [ 19 33 ] . However, the Smad3 responsive elements are different.
Of group I, pai-1 , pthrp and upa mRNAs were induced upon TGFβ treatment reaching maximum activation within three hours.