Words similar to pthrp

Example sentences for: pthrp

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The genes being examined were divided into two groups: I, known TGFβ target genes: pai-1, smad7, c-myc, upa and pthrp (Fig.
The strongest effect of SB-203580 was found on the TGFβ-dependent expression of pthrp and upa . In these cases, the inhibitor completely eliminated responsiveness to TGFβ.
PTHrP Exon 2 forward 5' AGGAGGCGGTTAGCCCTG 3'
TGFβ has been shown also to stabilize the mRNA of the smad7 gene [ 25 ] , while stabilization of RNA does not play a major role in regulation of the pthrp gene in MDA-MB-231 cells [ 19 ] . In addition, SB-203580 also inhibits p38 activity which has been shown to play a role in TGFβ signalling [ 36 37 38 39 40 41 ] . Hence, several factors could be responsible for the differential sensitivity of TGFβ-responsive genes to SB-203580.
We have previously demonstrated that TGFβ upregulates PTHrP and PAI-1 RNA levels in MDA-MB-231 cells [ 19 ] . TGFβ affected PTHrP expression primarily by increasing the level of the promoter P3-specific transcript [ 19 ] . Quantitative PCR analysis using primers allowing the detection of PTHrP P3 and PAI-1 transcripts indicated that incubation of MDA-MB-231 cells with SB-202190 and SB-203580 greatly inhibited TGFβ-induced increase in PTHrP and, to a lesser extent, PAI-1 mRNA levels (Fig.