Words similar to ptdins
Example sentences for: ptdins
How can you use “ptdins” in a sentence? Here are some example sentences to help you improve your vocabulary:
PtdIns(3,4)P2 and PtdIns(3,4,5)P3 recruit AKT (also known as protein kinase B [PKB]) to the membrane through the N-terminal pleckstrin homology (PH) domain of AKT [reviewed in ref.
First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.
The gene product of PTEN ( phosphatase and tensin homolog deleted from chromosome 10) is a lipid phosphatase that reverses the activities of phosphatidylinositol 3-kinase (PI3K) by dephosphorylating the D3 position of its lipid products, phosphatidylinositol-3, 4 bis-phosphate (PtdIns(3,4)P2), phosphatidylinositol-3,5 bis-phosphate (PtdIns(3,5)P2), and 3,4,5-tri-phosphate (PtdIns(3,4,5)P3) [ 2, 3], the elevated levels of which are linked to the transforming ability of PI3K [reviewed in ref.
PTEN -deficient human and mouse cells have elevated levels of intracellular PtdIns(3,4,5)P3 [ 10, 11] and demonstrate constitutive activation of AKT in the absence of growth factors [ 12, 13, 14].
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