Words similar to ptch

Example sentences for: ptch

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The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
However, uncoordinated movements, somnolence, or poor grooming, as is seen in PTCH animals developing tumors, were never observed.
The proteins showing allelic differences with multiple read coverage span a range of functional classes and include a zinc metalloprotease, 60S ribosomal protein, hyaluronic acid binding protein (gene Habp4 ), developmental related protein (gene Ptch ), transport system kinase and several genes for which no functional assignments have yet been made.
Haploid insufficiency for tumor suppressor genes, such as Nf2 , p27 Kip 1, p53 , Ptch , Pten and TGFβ , is known to promote tumor formation (reviewed in [ 44 45 ] ). Yamada et al.
Mice heterozygous for PTCH and lacking p53 all developed medulloblastomas by 3 months of age [ 12 ] .