Words similar to ptch

Example sentences for: ptch

How can you use “ptch” in a sentence? Here are some example sentences to help you improve your vocabulary:

Mutations in the Hedgehog pathway members PTCH , PTCH 2 , SUFU and Smo , have all been identified in sporadic medulloblastomas as well, with approximately 25% of cases containing mutations affecting these genes [ 5 6 7 8 9 ] . A murine medulloblastoma model was recently developed by disruption of the PTCH gene, with medulloblastoma-like tumors arising in 10-15% of heterozygotes by 9 months of age [ 10 11 ] . Breeding PTCH mice to p53 knockout animals markedly increased tumor incidence.
The rational for this approach was the markedly increased incidence of medulloblastomas seen in PTCH heterozygotes deficient for p53, and the enhanced intestinal adenoma phenotype of p53 null, APC heterozygous Min mice [ 12 32 ] . We did not observe any significant phenotypic changes in the CNS of β-catenin transgenic animals heterozygous or homozygous for disruption of the p53 locus.
Haploid insufficiency for tumor suppressor genes, such as Nf2 , p27 Kip 1, p53 , Ptch , Pten and TGFβ , is known to promote tumor formation (reviewed in [ 44 45 ] ). Yamada et al.
However, uncoordinated movements, somnolence, or poor grooming, as is seen in PTCH animals developing tumors, were never observed.
Mice heterozygous for PTCH and lacking p53 all developed medulloblastomas by 3 months of age [ 12 ] .