Example sentences for: ptc

How can you use “ptc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To test whether similar phenomena occur in mammalian cells with Hh protein and agonist, we generated stable cell lines expressing two epitope-tagged proteins, Ptc coupled to green fluorescent protein, Ptc-GFP, and Smo coupled to a fragment of influenza hemagglutinin, HA-Smo.

  • At 300 nM, a dose used to induce neuronal development in ES cell cultures [21], Shh produced a significant increase in neurite outgrowth in NS-derived cells (Figure 3D and 3E; see Methods), and resulted in increased Ptc expression (Figure 3F).

  • Similarly, specific point mutations in the transmembrane helices of Smo are capable of constitutively stimulating the pathway, effectively bypassing Ptc inhibition [ 3 ] . At present, a controversy surrounds the mechanism by which Ptc inhibits Smo.

  • Generation of Ptc1 lacZ , Shh and Smo mutant mice has been described previously [ 25 26 ] . Ptc1 lacZ /+mice were kindly provided by Matthew Scott.

  • TM3 cells expressing both epitope-tagged Ptc and Smo were derived by infecting first with an HA-Smo construct and subsequently with a Ptc-GFP construct.


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