Words similar to ptc

Example sentences for: ptc

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Ptc shares sequence homology with molecules associated with vesicle trafficking and transporter activity, namely SCAP and NPC1 [ 36 40 41 42 ] ; if it also shares the activities of these molecules, as suggested by a recent study [ 36 ] , then the possibility of the existence of endogenous Smo ligands that are docked via Ptc should be explored.
At 300 nM, a dose used to induce neuronal development in ES cell cultures [21], Shh produced a significant increase in neurite outgrowth in NS-derived cells (Figure 3D and 3E; see Methods), and resulted in increased Ptc expression (Figure 3F).
In particular, little is known about the means by which Ptc exerts its inhibitory effect on Smo, or how Smo communicates with the cytoplasmic Ci/Gli transcription factor complex.
Similarly, specific point mutations in the transmembrane helices of Smo are capable of constitutively stimulating the pathway, effectively bypassing Ptc inhibition [ 3 ] . At present, a controversy surrounds the mechanism by which Ptc inhibits Smo.
Taken together, these data suggest that Hh protein and the agonist share the ability to stabilize Smo, but only Hh protein can destabilize Ptc.