Words similar to ptec

Example sentences for: ptec

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Semi-quantitative analysis of the distribution and intensity of CD36-positive PTECs (CD36 PTEC score), which was performed by two independent pathologists in a blinded manner, demonstrated that mean CD36 PTEC scores were not different between FSGS kidneys and normal human kidneys, but were significantly increased in DNP kidneys (Figure 1K).
These in vivo findings demonstrate a strong association of diabetes-induced CD36 expression and apoptosis in PTECs in human DNP, suggesting that CD36 may play a critical role in TED by mediating PTEC apoptosis in progressive human DNP.
In contrast, CD36 mRNA and protein were not detectable in the murine PTEC line MCT at either normal or high ambient glucose concentrations (data not shown).
Increased CD36 expression mediates sequential activation of src kinase, proapoptotic p38 MAPK, and caspase 3 in PTECs in the presence of AGE and FFA PA, resulting in PTEC apoptosis.
Specifically, we show for the first time that both AGE and FFA PA induce PTEC apoptosis through CD36-mediated activation of src kinase, p38 MAPK, and caspase 3. Because high glucose stimulates CD36 expression in human PTECs and because CD36 expression is increased in apoptotic tubular epithelial cells in human DNP, we propose a two-step metabolic hit model relevant for TED, a hallmark of progression of human DNP.