Example sentences for: ptb
How can you use “ptb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Adaptor proteins that regulate tyrosine kinase signaling pathways fall into two major categories, those primarily with protein/protein interaction domains such as SH2, SH3, PTB, and PH domains, exemplified by the adaptor proteins c-crk, nck and grb-2, and those that are primarily tyrosine phosphorylated, exemplified by proteins such as Cas, Dok, IRS-1 and 2, Slp-76, LAT, TRIM or SIT.
Phosphorylation of these sites leads to recruitment of other proteins, including the first class of adaptor proteins with SH2 or PTB domains, and subsequent signal transmission (see [ 41 ] for review).
It has recently been suggested that G-protein coupled receptors with PDZ domains, SH2-containing domains and PTB domains participate in protein-protein interactions with partners other than G-proteins, such as Grb2 and JAK2, which may allow these receptors to bypass the G-proteins and utilize other signaling cascades (29).