Example sentences for: pla

How can you use “pla” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The name given Mallorca’s vast interior, Es Pla (“the plain”), may not sound promising.

  • Cytosolic PLA 2 specifically hydrolyzes sn-2 arachidonate from phospholipid providing the precursors for many different lipid mediators including prostaglandins and leukotrienes [ 1 2 ] . These lipid metabolites play a role in acute inflammatory responses and also regulate normal physiological processes.

  • The genes selected for confirmation were those for cyclin D1, GADD45, GPX, HO-1, HSP70, Mdr-1, QR, prostaglandin H synthase (PGHS), p21WAF1/CIP1 and PLA2.

  • Aristolochia rugosa and Aristolochia trilobata are recorded in a list of plants used worldwide and in the West Indies, Venezuela, South and Central America against snakebites and scorpion stings [ 51 52 24 43 40 53 ] . Caribs in Guatemala use Aristolochia trilobata root and tuber decoctions for stomach pains and use leaf tinctures for diarrhoea [ 55 ] . Aristolochic acid inhibits inflammation induced by immune complexes, and nonimmunological agents (carrageenan or croton oil) [ 56 ] . Aristolochic acid inhibits the activity of snake venom phospholipase (PLA 2 ) by forming a 1:1 complex with the enzyme [ 56 40 38 ] . Since phospholipase enzymes play a significant part in the cascade leading to the inflammatory and pain response, their inhibition could lead to relief of problems from scorpion envenomation [ 11 ] .

  • 2 , it is necessary to over-express the enzyme several fold as previously reported [ 16 ] . Cytosolic PLA 2 has been shown to mediate Ca 2+-induced AA release in MDCK cells treated with ATP and IONO in experiments using the group IV cPLA 2 α-specific inhibitor pyrrolidine-1 [ 27 ] . To measure cPLA 2 mediated AA release, EGFP-cPLA 2 -transfected MDCK cells labeled with [ 3H]-AA were incubated with 0.3, 1 or 10 μM U0126 for 15 min prior to stimulation with 100 μM ATP, 1 μM IONO, or 10 μM IONO.


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