Words similar to pkc
Example sentences for: pkc
How can you use “pkc” in a sentence? Here are some example sentences to help you improve your vocabulary:
PKC may bind to this anchoring protein through displacement of the pseudosubstrate, thus inhibiting the kinase activity, by analogy with a functionally similar scaffolding AKAP, AKAP79 [ 52 ] .
PKC has been suggested to play a role in synapse stability and signal transduction at the NMJ [ 24 ] . When calcium influx through the nAChR occurs, acetylcholine appears to activate PKC phosphorylation of this receptor [reviewed by [ 31 ] ]. Phorbol ester activation of PKC causes loss of synapses and nAChR [ 49 ] . Because the presynaptic PKCβ fluorescence band parallels the nAChR band (see fig.
Neurogranin has been shown to be phosphorylated by PKCγ, and this phosphorylation is greatly decreased in PKCγ knockout mice, suggesting neurogranin is a PKCγ-specific substrate [ 9 ] . Evidence that strongly suggests the phosphorylation of neurogranin plays an important role in neural plasticity comes from the studies that demonstrated neurogranin knockout mice show essentially the same deficits in behaviors related to learning and memory as that of the PKCγ knockout mice [ 10 ] . Neurogranin is not only a substrate of PKCγ, but also plays a important role in regulating PKC signaling [ 11 ] . Interstingly, PKCγ knockout mice demonstrate reduced neuropathic pain [ 12 ] . Similar to neurogranin, we found that a calmodulin-binding, vesicle-associated, CAM kinase IV-like protein is highly expressed and enriched in the superficial layer of the dorsal spinal cord.
Approximately 20% of the ORs do not have any serine or threonine residues in their carboxyl termini, whereas the remaining 80% have an average of more than two such residues, most of which are located in the vicinity of positively charged amino acids and conform to consensus sequences for phosphorylation by PKC or PKA.
More information has accumulated concerning PKC expression associated with the NMJ and skeletal muscle.
Loading...