Example sentences for: pkc

How can you use “pkc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, BIM can be used as a PKC inhibitor in rat pancreatic β-cells, as already shown in other tissues including murine macrophages [ 26 ] , rat adrenal cortex [ 27 ] , human melanocytes [ 28 ] and rabbit vetricular myocytes [ 20 ] .

  • In addition to a PKC binding site, gravin contains a PKA binding site.

  • Significantly, among the five subtypes of muscarinic ACh receptors (MAChRs), Ml and M3 receptors have been shown to efficiently activate PLD (and PKC) in various cell types [ 26 27 28 29 30 ] , whereas activation of PLD by M2 and M4 receptors is less robust [ 26 ] . These observations suggest that in a cholinergic synapse, ACh released into the synaptic cleft might stimulate PLD activity leading to a release of choline that could be used for ACh synthesis.

  • 7), it may be labeling the presynaptic membrane, consistent with reports of PKCβ localization to the presynaptic terminals of NMJs [ 22 23 ] . PKCβ initially associates with the cytoskeleton [ 50 ] . Phosphorylation at two places on the kinase core is required first to activate PKC, and second to release it from its cytoskeletal anchorage.

  • This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.

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