Example sentences for: pkb-α

How can you use “pkb-α” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is possible that NF-κB and CREB mediate the early phases of neutrophil activation, while C/EBP proteins function to maintain this response [ 50 ] . The observation that the temporal pattern of expression of activated C/EBP and PKB-α are similar suggests co-ordinated regulation of these proteins [ 51 ] . A decrease in activation of transcription factors like NF-κB and CREB and an increase in C/EBP may also contribute to reduced activity of pro-apoptotic genes, resulting in prolonged longevity of neutrophils in the lung vasculature.

  • However, in contrast to PI3K, the effects of endotoxin on PKB-α were transient.

  • This was correlated with induction of PKB-α.

  • A similar role has been suggested for these transcription factors in the response of intraparenchymal mononuclear cells to hemorrhage [ 50 ] . The fact that NF-κB and CREB activation occurs prior to expression of PI3K and PKB-α indicates that these transcription factors may regulate these proteins in lung neutrophils.

  • However our findings that PI3K levels remained elevated for 48 hours, while PKB-α decreased, suggest that PI3K regulates signaling pathways in adherent vascular neutrophils that are distinct from PKB-α.


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