Words similar to pkb-α

Example sentences for: pkb-α

How can you use “pkb-α” in a sentence? Here are some example sentences to help you improve your vocabulary:

However our findings that PI3K levels remained elevated for 48 hours, while PKB-α decreased, suggest that PI3K regulates signaling pathways in adherent vascular neutrophils that are distinct from PKB-α.
Inositol lipids generated via PI3K and downstream targets such as PKB-α have been implicated in the regulation of cell survival, as well as in induction of MAP kinases and TNF-α [ 45 46 47 ] . We found that endotoxin treatment of the animals caused a significant increase in expression of both PI3K and PKB-α at 12 hours, which is consistent with reduced apoptosis in these cells.
Our data also suggest that in lung neutrophils, PI3K and PKB-α are not co-ordinately regulated with chemotaxis, or expression of TNF-α or MAP kinases.
It is possible that NF-κB and CREB mediate the early phases of neutrophil activation, while C/EBP proteins function to maintain this response [ 50 ] . The observation that the temporal pattern of expression of activated C/EBP and PKB-α are similar suggests co-ordinated regulation of these proteins [ 51 ] . A decrease in activation of transcription factors like NF-κB and CREB and an increase in C/EBP may also contribute to reduced activity of pro-apoptotic genes, resulting in prolonged longevity of neutrophils in the lung vasculature.
The effects of acute endotoxemia on expression of PI3K and its downstream target PKB-α were also investigated.