Example sentences for: pkb

How can you use “pkb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, PTEN's protein phosphatase activity is able to down-regulate focal adhesion kinase (FAK) phosphorylation, which leads to the inactivation of the Ras/MAP kinase pathway [ 19 20 21 ] . Second, its lipid phosphatase activity targets the second messenger phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] and thereby blocks activation of the protein kinase B (PKB/Akt) pathway [ 11 18 22 23 24 ] . Whereas both of the above pathways are intimately involved in the control of cell growth and survival, PTEN-regulated FAK activity further appears to impinge on cell adhesion, cell migration, and cell invasion [ 20 21 ] . It therefore emerges that the loss of PTEN activity may confer increased survival ability, proliferative potential, and invasive capacity on cells, and thereby may promote progression towards a more malignant phenotype.

  • Activated PKB then phosphorylates GSK3β, inhibiting GSK3 kinase activity [ 29].

  • GSK3β is constitutively active in resting cells, and is inactivated by PKB through the growth factor dependent p110-PI 3-kinase pathway [ 25, 28, 29].

  • This activation of the p110-PI 3-kinase/PKB pathway, and inhibition of GSK3, delivers a strong anti-apoptotic signal to the cell [ 23, 24, 25].

  • Further, activation of the p110-PI 3-kinase/PKB is associated with inhibition of both p53 dependent apoptosis [ 48] and p53 transcriptional activity [ 49, 50].


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