Example sentences for: pkb

How can you use “pkb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • GSK3β is constitutively active in resting cells, and is inactivated by PKB through the growth factor dependent p110-PI 3-kinase pathway [ 25, 28, 29].

  • This activation of the p110-PI 3-kinase/PKB pathway, and inhibition of GSK3, delivers a strong anti-apoptotic signal to the cell [ 23, 24, 25].

  • PtdIns(3,4)P2 and PtdIns(3,4,5)P3 recruit AKT (also known as protein kinase B [PKB]) to the membrane through the N-terminal pleckstrin homology (PH) domain of AKT [reviewed in ref.

  • Further, activation of the p110-PI 3-kinase/PKB is associated with inhibition of both p53 dependent apoptosis [ 48] and p53 transcriptional activity [ 49, 50].

  • Activated PKB then phosphorylates GSK3β, inhibiting GSK3 kinase activity [ 29].


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