Words similar to pkb

Example sentences for: pkb

How can you use “pkb” in a sentence? Here are some example sentences to help you improve your vocabulary:

This activation of the p110-PI 3-kinase/PKB pathway, and inhibition of GSK3, delivers a strong anti-apoptotic signal to the cell [ 23, 24, 25].
Phosphorylation of GSK3β by PKB inhibits GSK3β kinase activity [ 29].
PtdIns(3,4)P2 and PtdIns(3,4,5)P3 recruit AKT (also known as protein kinase B [PKB]) to the membrane through the N-terminal pleckstrin homology (PH) domain of AKT [reviewed in ref.
GSK3β is constitutively active in resting cells, and is inactivated by PKB through the growth factor dependent p110-PI 3-kinase pathway [ 25, 28, 29].
It should be noted that the fibroblast cells lines we used remain fully viable after detachment and transfer to suspension culture [ 31 43 ] . This is in contrast to most epithelial cells which undergo anoikis, i.e., apoptotic cell death after the disruption of cell-matrix interactions [ 45 ] . It is of interest that some anchorage-independent tumor cells, most of which are of epitheloid origin, become susceptible to anoikis after the introduction of exogenous PTEN [ 23 34 35 36 ] . These observations are in line with the established ability of PTEN to down-regulate the phosphatidylinositol 3-kinase (PI3-K)/PKB survival pathway [ 11 46 ] . The absence of anoikis in our two cell lines may reflect inherent cell type specific differences, i.e., the superior ability of fibroblasts to survive under suspension culture conditions.