Words similar to pka
Example sentences for: pka
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The work reported here was undertaken to further understand the compartmentalization of PKA and PKC through association with AKAPs.
For PKA and PKC, the primary signal is generated at the plasma membrane and proceeds through intermediary G-proteins that stimulate adenylyl cyclase [ 1 ] or phospholipases [ 2 ] to generate the second messengers cAMP and diacylglycerol, respectively.
Approximately 20% of the ORs do not have any serine or threonine residues in their carboxyl termini, whereas the remaining 80% have an average of more than two such residues, most of which are located in the vicinity of positively charged amino acids and conform to consensus sequences for phosphorylation by PKC or PKA.
On the other hand, cAMP is known to participate in the growth and differentiation of varied cell types (including thymocytes), through the transcriptional regulation of specific genes [ 32 33 34 ] . The unique cAMP signaling which specifically targets the expression of the CD8 mRNAs (α and β), suggests that PKA activation may result in the transduction of signals that determine the selection of T lymphocytes in favor of the CD4 +CD8 -lineage, by down-regulating and possibly turning off the expression of the CD8 transcripts.
PKA association with mitochondria has been well documented [ 38 39 40 41 42 ] . In mammalian sperm, it was found that nearly all RII-specific labeling was with mitochondria [ 43 ] . Furthermore, in bovine heart, PKA activity was detected in the matrix or the matrix side of the mitochondrial inner membrane [ 44 45 ] . However, the work of Halestrap and coworkers provided little evidence for intramitochondrial protein phosphorylation by PKA, but gave some evidence for outer membrane phosphorylation, both integral and loosely bound proteins [ 46 47 48 ] . The localization of RIIα to the postsynaptic region beyond the postsynaptic membrane is consistent with part of the immunostaining of NMJs in the soleus muscle [ 18 ] , yet differs in part because there is no overlap with the bungarotoxin label; however, this is in agreement with another study [ 17 ] .
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