Example sentences for: pld

How can you use “pld” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • There are multiple neurotransmitters whose receptors are coupled to PKC-dependent activation of PLD [ 7 ] , and thus this mode of regulating the availability of choline for ACh synthesis is likely to be widespread.

  • A recent immunohistochemical study of PLD1 expression in rat brain showed that this PLD isoform was expressed in neurons in medial septum, cranial motor nuclei and ventral spinal cord [ 20 ] , all areas of the central nervous system enriched with cholinergic neurons.

  • In the present study, we used a cholinergic cell line, SN56 [ 17 ] , which is derived from the fusion of septal neurons of postnatal day 21 mice with N18TG2 murine neuroblastoma cells, as a model for cholinergic neurons, in order to determine the possible role of PLD 1 and PLD2 in generating choline for ACh synthesis.

  • The data are consistent with the report that a variant of PC12 cells also express exclusively PLD2 [ 18 ] and this expression is stimulated by nerve growth factor [ 18 ] , a treatment known to upregulate the cholinergic phenotype of PC12 cells [ 21 22 ] . PLD2 mRNA is abundant in many regions of the adult rodent central nervous system [ 6 23 ] , including cerebellum, frontal cortex, hippocampus, hypothalamus, midbrain, brainstem, striatum, and spinal cord [ 24 ] . The latter three regions are enriched with cell bodies of cholinergic neurons.

  • 5) indicating that choline generated by PLD1 was converted to ACh.


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