Words similar to pld-generated

Example sentences for: pld-generated

How can you use “pld-generated” in a sentence? Here are some example sentences to help you improve your vocabulary:

The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
Although it is clear that the PLD-generated choline is efficiently utilized by cholinergic cells (LA-N-2 and SN56) as a precursor of ACh, the quantitative significance of this pathway and mechanisms that regulate it remain to be fully determined.
Stimulation of PLD activity by PMA and the resulting increase of ACh synthesis from PLD-generated choline indicates that this pathway is regulated by PMA-responsive PKC isozymes.