Words similar to pld-generated

Example sentences for: pld-generated

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Stimulation of PLD activity by PMA and the resulting increase of ACh synthesis from PLD-generated choline indicates that this pathway is regulated by PMA-responsive PKC isozymes.
The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
Although it is clear that the PLD-generated choline is efficiently utilized by cholinergic cells (LA-N-2 and SN56) as a precursor of ACh, the quantitative significance of this pathway and mechanisms that regulate it remain to be fully determined.