Words similar to plcγ
Example sentences for: plcγ
How can you use “plcγ” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast, PLCγ2 was rapidly and highly phosphorylated after stimulation of BCR (lanes 5 and 8).
Thus parental and PLCγ2-deficient cells were transfected with kinase active Btk:ER and stable clones selected that expressed equivalent levels of Btk:ER, as measured by anti-Btk Western blotting of whole cell lysates (Fig 4A).
Together with our Btk:ER data, this suggests that Btk:ER controls sustained ERK activation in B cells by regulating PLCγ2 activity.
Since K430 is located on the smaller, NH 2 -terminal lobe of the kinase domain, whereas R525 is part of the larger, COOH-terminal lobe, it is possible that the two mutations differentially affect the capacity of kinase inactive Btk to function as an adapter in the activation of PLCγ2.
Thus Btk:ER appears to induce ERK activation through its capacity to activate PLCγ2, and not through a Grb2/Sos pathway.