Example sentences for: plcγ

How can you use “plcγ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In Fig 5we have tested whether PLCγ2 is required for Btk:ER-induced ERK and JNK activation, and apoptosis.

  • In response to PMA and ionomycin, activated JNK was detected in both WT and PLCγ2-deficient cells (Fig 5B, lanes 5 and 10).

  • To test whether PLCγ2 is required for Btk:ER-induced calcium mobilization, parental and PLCγ2-deficient cells expressing Btk:ER were treated with 4-HT and/or anti-μ, or ionomycin as a positive control (Fig 4B).

  • In Fig 5Cwe have investigated the mechanism by measuring Btk:ER-induced apoptosis in parental and PLCγ2-deficient cells.

  • Biochemical studies of Btk-deficient B cells have shown Btk to be necessary for BCR-induced phospholipase C-γ2 (PLCγ2) phosphorylation, calcium mobilization, extracellular signal-regulated kinase (ERK) and c-Jun NH 2 -terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation, NF-κB activation and apoptosis [ 7, 8, 9, 10, 11, 12].


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