Example sentences for: plc

How can you use “plc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The fact that U73343, which has essentially no effect on PLC at the concentrations employed [ 14 25 26 27 ] , is more potent than U73122 on MTX-induced responses, clearly shows that the effect of these agents is unrelated to inhibition of PLC.

  • Conglomeratization: Book publishing is dominated by seven media conglomerates : Paramount (Simon & Schuster), News Corp. (HarperCollins), Bertelsmann AG (Bantam Doubleday Dell), Advance Publications (Random House), Time Warner (Little, Brown), Pearson PLC (Viking Penguin), and Holtzbrinck (Holt).

  • It is however, well established that MTX causes the hydrolysis of phosphoinositides in some cell types, presumably via activation of phospholipase C (PLC) [ 12 13 ] . Activation of PLC by MTX appears to be indirect resulting as a consequence of increased [Ca 2+] i . These results suggest that PLC may be involved in activation of COP and/or in the cytolysis phase of MTX action.

  • And Wang [ 16 ] reported that U73343 suppressed elevation of [Ca 2+] i in neutrophils challenged with FMLP in the presence, but not the absence, of extracellular Ca 2+Both reports are consistent with a lack of effect of U73343 on receptor-mediated activation of PLC and a direct inhibitory effect on Ca 2+influx pathways in these cells.

  • Thus, the initial purpose of the present study was to determine the role of PLC in MTX-induced cell death.


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