Words similar to plc-γ

Example sentences for: plc-γ

How can you use “plc-γ” in a sentence? Here are some example sentences to help you improve your vocabulary:

Furthermore, we have found that combined mutation of Rlk and Itk leads to profound defects in TCR signaling associated with impaired activation of PLC-γ [ 20].
Recent data argue that Itk interacts directly with Slp-76 and Grb2 to participate in a LAT-nucleated T cell signaling complex involved in PLC-γ activation [ 5, 29].
In contrast, PLC-γ was not found in the RAFT fraction constitutively, but a portion became inducibly associated with RAFTs upon activation.
The importance of the Tec kinases in antigen receptor signaling was first demonstrated by the observation that mutations in BTK result in the human disease X-linked agammaglobulinemia (XLA) and the murine counterpart X-linked immunodeficiency ( xid ). These severe B cell immunodeficiencies are characterized by diminished numbers of mature B cells and reduced immunoglobulin levels associated with impaired PLC-γ activation and Ca ++mobilization in response to surface IgM stimulation (sIgM) [ 8, 9, 10, 11].
Finally, the presence of a highly active Syk enzyme in cells was insufficient for downstream signal transduction as evidenced by a lack of change in global tyrosine phosphorylation, phosphorylation of PLC-γ2 or enhanced spontaneous or induced apoptosis.