Words similar to plds
Example sentences for: plds
How can you use “plds” in a sentence? Here are some example sentences to help you improve your vocabulary:
The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
Most of the previous studies on the physiological functions PLDs have concentrated on the role of its product, PA [ 7 ] . Our data show that PLD has a dual function in cholinergic cells, as the second product of its activity, choline, is used as a metabolic precursor of ACh, and suggest that this pathway may be regulated by the type of PLD isoform expressed in a particular class of cholinergic neurons.
There are two distinct PC-specific mammalian PLDs, designated as PLD1 and PLD2 and encoded by separate genes [ 5 6 ] . The two enzymes share 50% amino-acid identity, however, regulation of their activity and cellular localization are different.
The pCGN expression vector containing the cDNAs of mouse PLD2 (mPLD2) or human PLD1 (hPLD1) driven by the CMV promoter were described previously [ 5 6 ] . An influenza-epitope (hemagglutinin-tag) is inserted in the pCGN vector and is expressed at the N-terminus of the PLDs.
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