Example sentences for: pks
How can you use “pks” in a sentence? Here are some example sentences to help you improve your vocabulary:
Finally, the nascent carbon chain adopts different folding patterns after it leaves the PKS, and ‘tailoring’ enzymes can then add sugars or other chemical groups to it at many alternative positions, enabled by the pattern of chemical reactivity built into the polyketide by the PKS.
Thus was born an ‘assembly line’ model in which the program for the PKS is hardwired into the DNA and expressed in a linear array of active sites (domains) along the giant protein.
A specific subunit of the PKS, named the chain length factor (CLF), was deduced to have a major influence on carbon chain length (McDaniel et al.
Thus, large amino acid residues in the CLF of a PKS that makes a 16-carbon chain were replaced by less bulky residues found in one that builds a 20-carbon chain, and the chain length of the product increased as expected.
Two recent publications by the Khosla laboratory at Stanford University describe significant advances in understanding aromatic PKS programming and promise to turn the spotlight back onto engineered members of this class of compounds as potential drug candidates by allowing rational manipulation of the two key variables: carbon chain length and choice of starter unit.
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