Words similar to pkr

Example sentences for: pkr

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For example, RP L18, which was significantly down-regulated by NGF, has been reported to negatively regulate double-stranded RNA (dsRNA)-activated protein kinase (PKR) [ 45 ] . As an additional example RP S19, which is also down-regulated by NGF, has been implicated in erythropoiesis and has also been described as a monocyte chemotactic factor [ 46 ] . As one last example, rat RP L9 which we found to be up-regulated by NGF starting within a few hours and maximally by 8 hrs, has been shown to be the ortholog of the yeast gene grc5 which appears to be involved in multiple cellular functions including growth control, cytoskeleton control and energy metabolism [ 47 ] . Identification of NGF-regulated RPs should now facilitate exploration of their potential roles in the responses of cells to neurotrophins.
As mentioned before, cytoplasmic dsRNA can trigger a series of signaling reactions that lead to interferon (IFN) synthesis [ 5 6 ] . In the "interferon response", dsRNA molecules activate protein kinase PKR and 2',5'-oligonucleotide synthetase.
One of the effects of PKR is to phosphorylate the α subunit of the general translation initiation factor eIF-2, which constitutes a major mechanism for global translation arrest.
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