Words similar to pkquest

Example sentences for: pkquest

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Some of the most comprehensive and sophisticated human PBPKs have been developed to describe the pharmacokinetics of volatile toxic solvents such as toluene [ 32 44 45 ] , styrene [ 46 47 ] , and methyl chloride [ 48 ] . The most involved models incorporate several different fat and muscle compartments with different flows and allow for changes with time in the blood flows as the subject's exercise level varies [ 45 47 48 ] . These studies have also introduced a Bayesian approach to determine the population distribution of the PBPK parameters [ 45 47 ] . PKQuest cannot complete with these PBPKs for this class of solutes.
The approach used by PKQuest is to first use the IV input data to find the PBPK parameters for ethanol, and then, using these parameters, solve for the time dependent IV input function that would produce a blood time course identical to the time course observed with the orally administered drug.
This analysis provides a good example of the advantage of a PBPK such as PKQuest over the more general compartmental (mamillary) model.
(PKQuest allows an arbitrary number of different organ concentrations to be simultaneously displayed).
The value of Tclr was obtained by using the Powell minimization routine that is built into PKQuest to optimize the fit to the blood data.