Words similar to mutated
Example sentences for: mutated
How can you use “mutated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Five productively rearranged genes were highly mutated with a range of 12 (F5-3a3) to 29 mutations to their respective germline (gl) gene.
Moreover, if some chemotherapeutic agents are not only directly cytotoxic to cancer cells, but also reduce tumor production of growth factors, such as IGF2 and TGFβ, adjuvant chemotherapy would be more useful in treating tumors with a mutated M6P/IGF2R , as observed in this study.
ARIX, which encodes a transcription factor critical to nIII and nIV development in mice and zebrafish [ 22 23 ] , was recently identified as the FEOM2 gene mutated in affected members of CFEOM2 families [ 5 ] . It was unknown, however, if classic CFEOM may also result from mutations in this gene.
These disorders were traditionally believed to reflect primary structural extraocular muscle (EOM) anomalies and have been referred to as 'congenital fibrosis syndromes' [ 1 ] . Neuropathology studies of DS [ 2 3 ] and one form of CFEOM (CFEOM1) [ 4 ] , and the identification of ARIX as the gene mutated in a second form of CFEOM (CFEOM2) [ 5 ] , however, support our hypothesis that CFEOM results from maldevelopment of the oculomotor (nIII) and/or trochlear (nIV) nuclei and DS results from maldevelopment of the abducens (nVI) nucleus.
They showed that the splice site at the 3' end of exon 7 was mutated from TAG GTATGT to TAG GTGTTG (where underlined sequence is the 3' end of exon 7 and ETn insertion sequence is in bold) and predicted that this site would be nonfunctional, thereby abolishing splicing of exon 7 to exon 8. They proposed that the T Wis allele would produce a transcript comprised of exons 1 through 7 followed by read-through transcription of the ETn element, resulting in a modified C-terminal end, or alternatively, that upstream splice donor sites would be used, shortening the transcript and protein product.
Loading...