Words similar to mutated
Example sentences for: mutated
How can you use “mutated” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
Importantly, the increase in reporter activity from Ets-1 expression was mediated by the Ets binding site on the CD5 promoter, as the increase in reporter expression did not occur when the Ets binding site on the CD5 promoter was mutated (lane 4 and 5).
To understand the effect of Ets-1 on CD5 expression, we co-transfected EL4 cells with increasing amounts of Ets-1 expression plasmid (pEVRF-ets-1) along with a StuI B reporter construct containing either the wild type (S) or mutated Ets binding site (E).
Second, molecules with the Y130E mutations did not co-immunoprecipitate with the BCR [ 58 ] . A second example involves an in vitro model of histamine release in the Syk-deficient RBL-2H3 cell line [ 59 ] . When tyrosines 519 and 520 were mutated and introduced into Syk-deficient RBL-2H3 cells, these Syk molecules were capable of phosphorylation of c3b substrate in an ICKA.
The Jewish contingent has exerted a particularly pervasive cultural influence (see Food, above [where available, high-quality Jewish delicatessen food is much esteemed], and note that several common jargon terms are obviously mutated Yiddish.
Loading...