Example sentences for: mutated

How can you use “mutated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These disorders were traditionally believed to reflect primary structural extraocular muscle (EOM) anomalies and have been referred to as 'congenital fibrosis syndromes' [ 1 ] . Neuropathology studies of DS [ 2 3 ] and one form of CFEOM (CFEOM1) [ 4 ] , and the identification of ARIX as the gene mutated in a second form of CFEOM (CFEOM2) [ 5 ] , however, support our hypothesis that CFEOM results from maldevelopment of the oculomotor (nIII) and/or trochlear (nIV) nuclei and DS results from maldevelopment of the abducens (nVI) nucleus.

  • Each of these cysteines was mutated to serine, and the effects on β1 integrin association were evaluated.

  • Yet the presence of a few members of this family that are more mutated (short ORFs, low LTR-LTR nucleotide identity) suggests that this may also be an ancient family.

  • This genetic manipulation takes place in embryonic stem (ES) cells, which once mutated, are introduced into the inner cavity of a blastocyst (very early mouse embryo), creating chimeric embryos that are put back into female mice that carry the pregnancy to term.

  • M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .


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