Example sentences for: mutations

How can you use “mutations” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While alanine mutants failed to disrupt the LcrG-LcrV interaction, radical mutations of three residues revealed a region important for the interaction.

  • There were 7-35 mutations in all other sequences.

  • APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.

  • Poor-quality sequences often present as novel singleton hits that closely resemble known genes, but encode potential proteins that are missing key residues, or contain apparent stop codons or frameshift mutations within functionally important regions.

  • At the upper bound of the range, a minimum of 17 observed mutations are required to detect negative selection at such a codon (0:17 is significantly lower than 1:4).


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