Words similar to mutational
Example sentences for: mutational
How can you use “mutational” in a sentence? Here are some example sentences to help you improve your vocabulary:
QUASI uses R:S to reject the null hypothesis that the mutational space surrounding the consensus codon is distributed randomly among all nine possible R or S point mutations (except stop codons, which are considered to be disallowed).
Of particular importance to this study are the genes p53 and K- ras 2 since a significant proportion of the mutations are localized to a relatively small number of mutational hotspots [ 13 14 15 16 ] . In this paper we introduce a screen to detect the presence of pancreatic cancer by looking for somatic mutations in p53 and K- ras 2 using polony technology to microsequence mutational hotspots within these two genes.
The slope of the resulting linear correlation gives evidence on how the protein sequence is affected by the mutational bias acting on the nucleotide sequence, and thus on how strongly the selection pressure acting on the protein can counteract this bias.
M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .
This mutational study is an effort to understand what structural features of the intron RNA are important for mobility and to utilize that information to construct a minimal intron capable of retrohoming.
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