Words similar to mutator

Example sentences for: mutator

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Oligonucleotide primers for the PCR reaction were based on the published sequence of murine Rab24 [ 24 ] . Kpn1 and BamH1 restriction sites were added to the 5' and 3' primers respectively, to facilitate cloning of the PCR product in frame with a 5' sequence cassette encoding a myc epitope (EQKLISEEDL), previously introduced into the pCMV5 expression vector [ 78 ] . The Rab24 cDNA was altered by overlap-extension PCR [ 79 ] , using appropriate mutator oligonucleotides and Pfu DNA polymerase (Stratagene Inc., La Jolla, CA), so as to introduce amino acid substitutions at D123 (D123I), T120 (T120A), S22 (S22N), S67 (S67Q), and a deletion of residues 127 through 130 (ΔEDRR).
HSV-2 6757, although not 6757PR, conferred a slightly higher proportion of mutations in non-HSV DNA in the plasmid assay, than wild type HSV-1 and HSV-2, consistent with a mutator phenotype.
cDNA clones were from three, non-normalized cDNA libraries: a mixture of adult tissue (projects 707 and 945, W23 inbred line with active Mutator transposons), 4-day-old roots (project 614, W23 inbred line), and immature ears (project 606, Oh43 inbred line).
Thus, classification of a pol gene as mutator (HSV-2 6757) or antimutator (PAA r5) is not a general characteristic, but is likely dependent upon the assay method and target gene.
The control viruses, HSV-2 6757 and HSV-1 PAA r5, demonstrated mutator or antimutator phenotypes, respectively, in the tk mutagenesis assay, but not in the non-HSV DNA mutagenesis assay.