Example sentences for: mutagenesis

How can you use “mutagenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, PfPP5 contained the catalytic core found in all Ser/Thr phosphatases of the PPP family, including the signature motifs such as GDXHGQ, GDFVDRG, RGNHE, HGLL, and SAPNYCD, to name a few [ 22 23 ] . Site-directed mutagenesis and structural studies in PP 1 and PPλ have previously established the roles of specific amino acid residues in these domains in the various aspects of catalysis, such as metal ion binding, phosphate recognition, and co-ordination of water molecules [ 24 25 26 ] .

  • Mutagenesis was carried out using the Altered Sites Mutagenesis System (Promega, Wl) as previously described by us [ 33].

  • Mutagenesis [ 14 ] , X-ray crystallography [ 16 40 ] , and stereochemical analysis [ 41 ] indicate that His96 is the nucleophile that attacks the α-phosphate of Fhit substrates.

  • This result accords with mutagenesis experiments that have pinpointed acidic residues and phenylalanine as special contributors to transactivation [ 23 28 ] .

  • Silent mutations within the tk gene that do not impair susceptibility to antiviral agents, or mutations resulting in lethality of the virus, would escape detection as a mutation in the tk mutagenesis assay.


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