Example sentences for: mutagenic

How can you use “mutagenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Oxoguanine has become the benchmark for oxidative DNA modifications; it is arguably the most important mutagenic lesion in DNA (mispairing with adenine during chromosomal replications causes GC → TA transversions) [ 24 ] . It is suggested that untoward oxidative stresses to DNA prompt cell-cycle delay, antiapoptotic, and repair responses.

  • Mutations can be introduced during replication by the viral proteins or also by the mutagenic processes of transfection and viral infection.

  • The sequences of all mutagenic oligonucleotides are available upon request.

  • Since the process of transfection is often mutagenic, pSV110 was transfected into Vero cells, mock-infected and rescued into bacteria to determine background frequency of mutation from the experimental process.

  • Most recently, the crystal structure of the polymerase in complex with a DNA promoter has revealed the structural basis for this specificity [ 1 2 ] . In addition, a number of researchers have examined the contribution of various nucleotides and functional groups in the promoter and various amino acids in the polymerase to specificity [ 3 4 5 ] . Based upon both structural and mutagenic analyses, it has proven possible to identify polymerase variants with altered specificities for promoters [ 6 7 ] . Polymerase variants with altered specificities have also been identified using genetic selections [ 8 ] . However, the variant polymerases and variant promoters that have so far been identified are close in sequence to the wild-type.


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