Words similar to mutagenic
Example sentences for: mutagenic
How can you use “mutagenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Oxoguanine has become the benchmark for oxidative DNA modifications; it is arguably the most important mutagenic lesion in DNA (mispairing with adenine during chromosomal replications causes GC → TA transversions) [ 24 ] . It is suggested that untoward oxidative stresses to DNA prompt cell-cycle delay, antiapoptotic, and repair responses.
Most recently, the crystal structure of the polymerase in complex with a DNA promoter has revealed the structural basis for this specificity [ 1 2 ] . In addition, a number of researchers have examined the contribution of various nucleotides and functional groups in the promoter and various amino acids in the polymerase to specificity [ 3 4 5 ] . Based upon both structural and mutagenic analyses, it has proven possible to identify polymerase variants with altered specificities for promoters [ 6 7 ] . Polymerase variants with altered specificities have also been identified using genetic selections [ 8 ] . However, the variant polymerases and variant promoters that have so far been identified are close in sequence to the wild-type.
Recent advances, such as the application of mutagenic screens to study fin regeneration in zebrafish (Johnson and Weston 1995; Poss et al.
The sequences of all mutagenic oligonucleotides are available upon request.
The Neo 3' splice site contains a potential branch point sequence, and the sequence (CAGG) across the intron-exon boundary is optimal according to the scanning model of 3' splice site selection [ 54 55 ] . The Neo site differs from the typical 3' splice site in that it lacks a polypyrimidine tract; however, this feature is often missing from alternative splice sites [ 56 ] . Both the A of the branch point and the intron-terminal AG dinucleotide are considered invariant; therefore, one may be able to enhance the mutagenic efficiency of U3Neo vectors by altering these nucleotides.
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