Words similar to mutagenic
Example sentences for: mutagenic
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Most recently, the crystal structure of the polymerase in complex with a DNA promoter has revealed the structural basis for this specificity [ 1 2 ] . In addition, a number of researchers have examined the contribution of various nucleotides and functional groups in the promoter and various amino acids in the polymerase to specificity [ 3 4 5 ] . Based upon both structural and mutagenic analyses, it has proven possible to identify polymerase variants with altered specificities for promoters [ 6 7 ] . Polymerase variants with altered specificities have also been identified using genetic selections [ 8 ] . However, the variant polymerases and variant promoters that have so far been identified are close in sequence to the wild-type.
Mutations can be introduced during replication by the viral proteins or also by the mutagenic processes of transfection and viral infection.
Since the process of transfection is often mutagenic, pSV110 was transfected into Vero cells, mock-infected and rescued into bacteria to determine background frequency of mutation from the experimental process.
Oxoguanine has become the benchmark for oxidative DNA modifications; it is arguably the most important mutagenic lesion in DNA (mispairing with adenine during chromosomal replications causes GC → TA transversions) [ 24 ] . It is suggested that untoward oxidative stresses to DNA prompt cell-cycle delay, antiapoptotic, and repair responses.
The Neo 3' splice site contains a potential branch point sequence, and the sequence (CAGG) across the intron-exon boundary is optimal according to the scanning model of 3' splice site selection [ 54 55 ] . The Neo site differs from the typical 3' splice site in that it lacks a polypyrimidine tract; however, this feature is often missing from alternative splice sites [ 56 ] . Both the A of the branch point and the intron-terminal AG dinucleotide are considered invariant; therefore, one may be able to enhance the mutagenic efficiency of U3Neo vectors by altering these nucleotides.
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