Words similar to mutant
Example sentences for: mutant
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Instead of remaining in the cytoplasm in the absence of steroid, nearly all of the GR-GFP was found in the cytoplasmic and nuclear inclusion bodies containing the Rab24 mutant (Fig.
Fridovich and colleagues first noticed the presence of SOD1 in the intermembrane space in liver mitochondria [ 37 ] . Although this was disputed later [ 38 39 ] , recent experiments in yeast and mammalian cells reaffirmed the presence of both wild type and mutant SOD1 in the intermembrane space of mitochondria [ 21 25 26 40 ] . This finding suggests that mutant SOD1 could directly damage mitochondria by its toxicity.
Extinction of mutant for μ = 0
Analysis of the DNAs on denaturing gels revealed that the negative polarity DNA synthesized by the D715V mutant was annealed to a complementary strand [ 23], indicating that it was in an RNA:DNA heteroduplex.
[ 11 12 13 14 ] . Kidney transplants between normal and transgenic Tg26 siblings suggested that specific HIV-1 proteins within the kidney, and not circulating factors, transform infected renal epithelium [ 13 ] . Indeed, HIV-1 transgenic mice generated with an HIV-1 proviral construct mutated in the Nef "PXXP" SH3-binding motif for Src-family kinases failed to develop nephropathy [ 31 ] , and a recent in vitro analysis of podocytes infected with single gene mutants of HIV-1 further suggest that Nef plays a central role in causing the proliferative phenotype in HIVAN [ 8 ] . Utilizing these same single gene mutant viruses, we showed here that Nef appears to be play a role in the up-regulation of cyclin D 1 by HIV-1 in vitro . Importantly, these single gene mutants do not exclude the possibility that other HIV-1 gene(s) may cooperate with nef to induce cyclin D1, particularly