Words similar to heterodimerization
Example sentences for: heterodimerization
How can you use “heterodimerization” in a sentence? Here are some example sentences to help you improve your vocabulary:
Both type I and type II BMPRs bind their respective ligands, but heterodimerization is required for a signal to be transduced [ 34, 35].
As cooperativity is difficult to invoke in this system, we consider that for Asw to titrate Hint enzyme activity by heterodimerization, Asw must carry a signal for mislocalization and/or proteolysis, and/or somehow alter the Hint active site.
Although the initial cloning of ASW pre-dated knowledge that Hint is an enzyme, both groups suggested that Asw might function by a dominant-negative mechanism through heterodimerization with Hint, thereby inducing female development [ 33, 34].
Runx genes encode the sequence-specific DNA binding subunit of a heterodimeric transcription factor, the defining feature of which is the Runt domain, a highly conserved 128 amino acid sequence involved in DNA binding, heterodimerization, nucleotide binding, and nuclear localization [ 1 2 ] . The Runt domain is named after the first member of the family to be discovered, the regulatory gene runt from Drosophila melanogaster . Runx genes have also been discovered and functionally characterized in mammals, sea urchins and nematodes, and in general are involved in the transcriptional control of developmental processes [ 3 4 ] . In humans, mutations in each of the three Runx genes are associated with disease caused by defective control of cell proliferation and/or differentiation [ 4 5 ] . Most studies of Runx gene function and regulation have been carried out in mammals and in D. melanogaster , each of which has multiple Runx genes.
The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.
Loading...