Example sentences for: heterodimerization

How can you use “heterodimerization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Both type I and type II BMPRs bind their respective ligands, but heterodimerization is required for a signal to be transduced [ 34, 35].

  • It is tempting to speculate that the gain of an additional cysteine in sterolin-1 by the Gly583Cys missense mutation might affect intracellular trafficking or the heterodimerization with sterolin-2.

  • Although the initial cloning of ASW pre-dated knowledge that Hint is an enzyme, both groups suggested that Asw might function by a dominant-negative mechanism through heterodimerization with Hint, thereby inducing female development [ 33, 34].

  • As cooperativity is difficult to invoke in this system, we consider that for Asw to titrate Hint enzyme activity by heterodimerization, Asw must carry a signal for mislocalization and/or proteolysis, and/or somehow alter the Hint active site.

  • The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.


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