Words similar to heterodimers
Example sentences for: heterodimers
How can you use “heterodimers” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because one binding site remains intact, such mutant-wild-type heterodimers are functional repressors (except in cases where the mutation affects a residue that plays a role in both half-sites).
NAC is an antioxidant thiol that raises the intracellular pool of glutathione the major redox regulating mechanism in the A549 epithelial cell line [ 45 ] . Interestingly, it has been reported that NAC can have differential effects on NF-κB binding activity suggesting only a subset of NF-κB binding complexes are redox sensitive [ 58 ] . Moreover, it has been shown that NAC inhibits Rel A/p50 heterodimers but not p50 homodimers and can inhibit NF-κB binding to only certain variant κB elements which presumably interact with distinct redox sensitive NF-κB binding complexes [ 59 ] . These observations are consistent with our findings that indicate NAC predominantly inhibits Rel A homodimers since that was the major NF-κB subunit induced by RSV infection of A549 cells.
We utilized a monoclonal antibody screening method involving co-immunoprecipitation of integrins under non-stringent detergent conditions [ 30 31 ] . Using this approach, we have previously discovered specific associations between particular β1 integrins and other cell surface molecules including CD147/EMMPRIN [ 31 ] , and various tetraspanin (transmembrane-4 superfamily) proteins [ 30 32 33 ] . In this report we demonstrate for the first time that CD98 constitutively and specifically associates with intact β1 integrin heterodimers.
This was also the case with the mutants we describe here, all of which formed normal or near normal amounts of capsids in single-chain homodimers and in their heterodimers with wild-type, Y85H and T91I (results not shown).
The structures of the three heterodimers in the crystal are essentially identical, with an average RMSD of 0.68 Å on all atoms.
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