Words similar to heterologous
Example sentences for: heterologous
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In heterologous expression systems, the α 2 -δ subunit was shown to affect the rate of Ca 2+current inactivation and charge movement immobilization [ 33].
Metabotropic glutamate receptors (mGluRs) are a family of class 3 G protein-coupled receptors with important functions in the regulation of synaptic transmission, plasticity, neuronal excitability, and the regulation sensory transduction [ 1 2 3 4 5 ] . The eight mGluRs (mGluR1-8) and their splice variants have been divided into three groups (I-III) based on sequence homology, pharmacology and G protein coupling profiles [ 3 6 7 ] . Group II (mGluR2 and 3) and III (mGluR4, and 6 through 8) couple negatively to adenylate cyclase through activation of the G i/o family of G proteins [ 8 ] . Group I mGluRs (mGluR1 and 5) couple to multiple G proteins in native and heterologous systems, and have been observed to couple to G q/11 , G i/o and/or G s [ 9 10 11 12 13 14 15 ] . mGluRs appear to be important mediators of synaptic transmission in the brain.
Heterologous genes were cloned into the previously described Δpre-M/E replicon [ 12 ] , into the position previously occupied by the pre-M/E genes.
Alternatively, the presence of heterologous Etn element sequences in T Wis transcripts may stimulate posttranscriptional gene silencing by an RNA-induced silencing complex (RISC)-based RNAi degradation pathway which could target degradation of wild type transcripts [ 14 ] .
Triplicate dishes of SCC25 cells were transiently transfected with 5 μg luciferase reporter construct containing a heterologous promoter containing a consensus AP-1 site 5'-TGACTCA-3' [ 11 ] . 2 μg of wild type or S77A mutant RARα expression vector was cotransfected to determine the effects of RARα phosphorylation on AP-1 promoter activity.
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