Words similar to heterotrimeric
Example sentences for: heterotrimeric
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Kinesin-interacting protein KAP3 that has armadillo repeats is thought to mediate cargo binding as part of a heterotrimeric complex with two kinesins in the KRP85/95 subfamily [ 18].
GPCRs stimulate heterotrimeric G proteins which release activated Gα and Gβγ subunits to interact with a variety of effectors.
It includes Far1p, a protein necessary for pheromone-induced cell cycle arrest in G1 [ 11 ] , Mpt5p, a protein necessary for recovery from cell cycle arrest [ 12 ] , and Bem1p and Sph1, both of which are necessary for establishment of cell polarity during shmooing and budding [ 13 14 ] . In our protein-interaction map there is no direct interaction between a pheromone receptor (Ste2p or Ste3p) and any component of the heterotrimeric G protein complex (Ste4p/Ste18p/Gpa1p), so NetSearch drew indirect paths through Akr1p, a known inhibitor of signaling in the pheromone pathway [ 15 ] . The predicted network does not include the GTPase Cdc42p (paths were instead drawn preferentially through its cofactor Cdc24p, which physically interacts with Ste4p) or Ste20p, because of missing interactions in the protein-interaction map.
In addition to their well characterized role at the PM in coupling activated GPCRs to effector proteins, heterotrimeric G proteins have been implicated in a variety of other cellular functions, including membrane trafficking pathways.
Bitter compounds bind to a family of G protein-coupled receptors called the T2R [ 14, 15] or TRB [ 16] receptors, which activate a heterotrimeric G protein consisting of α-gustducin and a βγ complex containing β3 [ 17] and γ13 [ 8].
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