Words similar to heterozygote
Example sentences for: heterozygote
How can you use “heterozygote” in a sentence? Here are some example sentences to help you improve your vocabulary:
To determine the precise conditions under which population heterozygote advantage will be observed, we consider a general model that predicts the expected outcome of a comparison between heterozygotes and homozygotes in an epidemiological study as a function of (i) the frequencies of resistant and susceptible alleles at a particular locus and (ii) the relationship between genotype at that locus and phenotype.
Population heterozygote advantage corresponds to RR > 1. Various formulations for relative risk (or odds ratio, used in case-control studies, such as [ 6 ] ) are used in studies of HLA heterozygosity and disease outcome, but in all cases the cutoff is one and a value larger or smaller than one (depending on the precise definition used) corresponds to population heterozygote advantage.
In each case, population heterozygote advantage, shown as the black region and corresponding to RR > 1, is most likely when resistant alleles are highly diverse and susceptible alleles have low diversity (bottom right of each panel).
In many cases, heterozygotes as a group have shown better infectious disease outcomes (slower disease progression or more rapid clearance of viral infection) than homozygotes as a group [ 5 6 8 9 14 22 ] , a phenomenon we call "population heterozygote advantage."
Put another way, population heterozygote advantage may appear due to a combination of the two distinct mechanisms we defined in the Introduction: the protective or detrimental effects of particular alleles (R and S alleles in our model), and the effects of heterozygosity itself.
Loading...