Words similar to heterozygote
Example sentences for: heterozygote
How can you use “heterozygote” in a sentence? Here are some example sentences to help you improve your vocabulary:
We selected 25 Arg +transformants and analyzed them by Southern blotting for integration of the UAU1 cassette into one of the two CaCET1 chromosomal loci to yield the heterozygote CaCET1/cacet1::UAU1 configuration depicted in Figure 1. Briefly, genomic DNA was isolated from the 25 Arg +strains, then digested with Sca I (which cuts neither CaCET1 nor UAU1 ). The digests were resolved by agarose gel-electrophoresis and transferred to membranes, which were probed with a radiolabeled DNA corresponding to the 5' segment of CaCET1 (probe A in Figure 1).
Thus, heterozygotes on average will be 1.26 times more likely to have a favorable outcome, even though each heterozygote has the same outcome as if s/he were homozygous for the worse of the two alleles s/he carries.
Of the two ways described above in which MHC genotype may affect disease outcome, the first - association between a particular allele and disease outcome - has been repeatedly documented in human populations by various methods of genetic epidemiology [ 17 ] . The second kind of effect, more vigorous immune responses to a pathogen by a heterozygote as compared to homozygotes for the same alleles, which we term "allele-specific overdominance," has been suggested by several animal studies [ 18 19 20 21 ] , although none of these studies is unambiguous (see DISCUSSION).
We found that 3/26 Arg +Ura +segregants emanating from a CES1/ces1::UAU1 heterozygote were homozygous for disruption at both loci ( ces1::UAU1/ces1::URA3 ) and had lost the wild-type CES1/ZDS1 allele [B.
Put another way, population heterozygote advantage may appear due to a combination of the two distinct mechanisms we defined in the Introduction: the protective or detrimental effects of particular alleles (R and S alleles in our model), and the effects of heterozygosity itself.
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