Example sentences for: heterozygote

How can you use “heterozygote” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It can also accommodate overdominance of the resistant alleles ( a > 1; b > d ; c > d ), in which each heterozygote does better than either corresponding homozygote, and underdominance, in which each heterozygote does worse than either corresponding homozygote ( a < 1; b < 1; c < d ). In this model, susceptibility and resistance are relative and simply refer respectively to lower and higher probabilities of favorable disease course, given infection.

  • The relative risk (RR) of a favorable outcome for a heterozygote compared to a homozygote is defined as:

  • Figure 1shows that allele-specific overdominance (the biological phenomenon of interest) and population heterozygote advantage (the finding of epidemiological studies such as those cited above) are two different things.

  • When allele frequencies are equal, as in Example 1, partial dominance is sufficient to create population heterozygote advantage [ 10 11 ] . When allele frequencies differ, the conditions for population heterozygote advantage may become broader or narrower.

  • Using the relative risk equation above, it can be shown by taking partial derivatives with respect to the parameters p , Π and Θ, that (under the assumptions stated above) the relative risk increases with p and Θ and decreases with Π. Thus, population heterozygote advantage is most likely to be observed when resistant alleles are common ( p large) but highly diverse (Π is small), and when susceptible alleles are not diverse (large Θ).


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