Words similar to heterozygote
Example sentences for: heterozygote
How can you use “heterozygote” in a sentence? Here are some example sentences to help you improve your vocabulary:
Simple and accurate methods exist to determine for a single pair of alleles how the three possible genotypes (2 homozygotes and one heterozygote) affect disease outcome, and these methods have been used frequently in the literature on autoimmunity and HLA [ 28 29 30 ] and once (to our knowledge) in the HLA-infectious disease literature [ 33 ] . It is of additional interest for epidemiologists, immunologists, vaccine designers and evaluators, and population geneticists to know whether HLA heterozygosity in general improves the immune response to and outcome of infectious diseases.
These were embryonic lethals, but when we looked at heterozygote carriers of these mutations, some developed cancer at a high rate as adults’.
In many cases, heterozygotes as a group have shown better infectious disease outcomes (slower disease progression or more rapid clearance of viral infection) than homozygotes as a group [ 5 6 8 9 14 22 ] , a phenomenon we call "population heterozygote advantage."
Thus, heterozygotes on average will be 1.26 times more likely to have a favorable outcome, even though each heterozygote has the same outcome as if s/he were homozygous for the worse of the two alleles s/he carries.
The foregoing examples show that the finding of population heterozygote advantage, as in the infectious disease studies cited, does not support an inference of allele-specific overdominance, the condition of primary interest as an immunological hypothesis and a mechanism for the maintenance of MHC diversity.
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