Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
Six different gene-specific polymorphisms were used to assess head and neck tumors for M6P/IGF2R loss of heterozygosity [ 32 33 ] .
In epidemiological terms, this is a form of confounding, in which possession of a resistant allele is positively associated with heterozygosity (the exposure of interest) and positively associated with having a favorable disease course (the outcome of interest).
We have shown that polony technology is an improved method to study, and potentially diagnosis, cancer [ 22 ] . Specifically, polony technology was successfully applied to both detect intragenic mutations in well-defined mutational hotspots in key cancer genes as well as determine if loss of heterozygosity of these same genes had occurred.
Comparative genomic hybridization (CGH), a molecular cytogenetic method that identifies chromosomal gains and losses, and loss of heterozygosity (LOH) studies have also demonstrated recurrent deletions on the 5p in precancerous lesions [ 7 8 9 10 ] . Although, these studies have identified 5p as a commonly affected region, the precise site of deletion that harbor putative TSG is unknown because of the lack of systematic and detailed deletion mapping studies.
Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.
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