Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
Entire lobules and large ducts of normal breast tissue can be derived from a single progenitor cell [ 47 ] , and LOH at various chromosomal locations is frequently detectable in morphologically normal lobules adjacent to breast tumors [ 48 ] . Lung tumors and head and neck tumors that develop in a localized region also often have a common clonal origin [ 3 4 49 ] . The high frequency of M6P/IGF2R loss of heterozygosity observed in the head and neck tumors in this study suggests that the phenomenon of "field cancerization", first described by Slaughter and his colleagues [ 2 ] in 1953, may in part result from the clonal proliferation of mucosal epithelial cells with M6P/IGF2R allelic loss.
Since chromosomal deletion can affect more than one gene, M6P/IGF2R loss of heterozygosity alone does not rule out the possibility that other adjacent genes also have a tumor suppressor function in head and neck cancer.
This provides evidence that M6P/IGF2R loss of heterozygosity in head and neck cancer is due primarily to either gene deletion or chromosomal loss rather than somatic recombination.
Optimal properties of an STRP include: high heterozygosity, strong and specific PCR amplification, capability to be amplified simultaneously with other STRPs (multiplexed), sharp bands on gels, easy and accurate scoring of allele sizes, relatively low mutation rate, and appropriate position along the genetic map.
Although somatic mutations in the gene have been detected in only about 1% of breast cancers, loss of heterozygosity (LOH) at the PTEN locus (10q23) is frequently found (approximately 40%), and 33% of breast tumors have no detectable, or reduced, levels of the protein product [ 18, 19, 20, 21, 22].
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