Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
In epidemiological terms, this is a form of confounding, in which possession of a resistant allele is positively associated with heterozygosity (the exposure of interest) and positively associated with having a favorable disease course (the outcome of interest).
Average heterozygosity will be calculated.
M6P/IGF2RLoss of Heterozygosity Analysis
M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .
A study in mice of resistance to Toxoplasma gondii showed that F 1 offspring of two genetically divergent parent strains were more resistant than either parent strain, but there seems to be no demonstration that heterozygosity at an MHC locus is responsible [ 18 ] , while another reference [ 19 ] that has been cited [ 10 ] as showing overdominance at MHC in the same host-pathogen system does not appear to address the question directly.
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