Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
One hallmark of cancer that can be readily observed using polonies is loss of heterozygosity (LOH).
The clinical trial from which the tumor specimens used in this study were derived showed improvements in relapse-free survival, locoregional control, and overall survival for those patients randomized to combined modality therapy [ 31 ] . This investigation established that patients whose tumors had M6P/IGF2R loss of heterozygosity and were treated with radiotherapy alone had a significantly worse prognosis than their counterparts with a non-mutated allele.
Loss of heterozygosity in cancer can occur either because of chromosomal deletion or somatic recombination resulting in uniparental disomy [ 37 ] . Comparative genomic hybridization studies in head and neck cancer [ 10 38 ] demonstrate that 6q deletion frequency (> 50%) is similar to that which we observed at the M6P/IGF2R locus.
CIS, carcinoma in situ ; HCC, hepatocellular carcinoma; IGF2, insulin-like growth factor 2; LOH, loss of heterozygosity; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; TGFβ, transforming growth factor beta; UTR, untranslated region.
Heterozygosity estimates of the Set 10 (and many Set 12) STRPs are also available from genotyping of the Human Diversity Panel [see Marshfield web site and reference [ 27 ] ].