Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
M6P/IGF2R loss of heterozygosity occurs frequently in human breast, liver and lung cancer [ 6 20 21 22 ] , and the remaining allele of 30 to 50% of these tumors contains an intragenic loss-of-function point mutation in the ligand binding domains [ 35 ] . The M6P/IGF2R is also commonly mutated in gastrointestinal and endometrial malignancies because its coding sequence contains a poly-G region that is a mutational target in tumors with mismatch repair deficiencies and microsatellite instability [ 23 24 ] . Functional studies show that the introduction of an exogenous wild-type M6P/IGF2R into human colorectal cancer cells with a single inactivated allele significantly decreases growth rate and enhances apoptosis [ 26 ] . Conversely, loss of M6P/IGF2R expression promotes cancer cell growth by increasing intracellular signaling from both the insulin-like growth factor I receptor and the insulin receptors [ 36 ] .
This provides evidence that M6P/IGF2R loss of heterozygosity in head and neck cancer is due primarily to either gene deletion or chromosomal loss rather than somatic recombination.
And, indeed, it was shown that in the tumours in these predisposed patients, the remaining wild-type copy of the tumour suppressor gene was lost, a process referred to as loss of heterozygosity.
Optimal properties of an STRP include: high heterozygosity, strong and specific PCR amplification, capability to be amplified simultaneously with other STRPs (multiplexed), sharp bands on gels, easy and accurate scoring of allele sizes, relatively low mutation rate, and appropriate position along the genetic map.
The observations in this study raise the intriguing possibility that selection of head and neck cancer patients for concurrent chemotherapy can be based upon the intratumoral mutational status of M6P/IGF2R . Furthermore, since M6P/IGF2R loss of heterozygosity in squamous cell carcinomas is highly correlated with an elevated plasma TGFβ level [ 39 ] , patient prognosis may potentially be assessed by a simple blood test.
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