Words similar to heterozygosity
Example sentences for: heterozygosity
How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:
We tested in this investigation the hypothesis that M6P/IGF2R loss of heterozygosity in locally advanced, non-metastatic squamous cell carcinomas of the head and neck is associated with poorer patient prognosis.
Herein, we describe the applications of polony technology to cancer research with the goal of screening for: 1) mutations in key tumor suppressor and oncogenes; as well as 2) loss of heterozygosity.
Frequent allelic loss at chromosomal locations 2q, 3p, 4q, 6p, 6q, 8p, 8q, 9p, 11q, 13q, 14q and 17q is observed in head and neck cancer [ 4 8 9 10 11 ] . Molecular studies of hyperplastic, dysplastic, CIS, and invasive head and neck lesions indicate that loss of heterozygosity at chromosomal locations 3p, 9p and 17p are early events in head and neck carcinogenesis [ 4 12 ] . Specific tumor suppressor genes, such as FHIT (3p14.
A study in mice of resistance to Toxoplasma gondii showed that F 1 offspring of two genetically divergent parent strains were more resistant than either parent strain, but there seems to be no demonstration that heterozygosity at an MHC locus is responsible [ 18 ] , while another reference [ 19 ] that has been cited [ 10 ] as showing overdominance at MHC in the same host-pathogen system does not appear to address the question directly.
These genes include PITX2, PITX3, PAX6, FOXC1 (previously known as FKHL7 and FREAC3), Foxc2 and FOXE3 [ 4 5 6 7 8 9 ] . Activity levels for these transcription factors normally associated with diploid gene dosage are important for normal ocular development, with heterozygosity for null mutations in most of these genes causing anterior segment dysgenesis.
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