Example sentences for: heterozygosity

How can you use “heterozygosity” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • One hallmark of cancer that can be readily observed using polonies is loss of heterozygosity (LOH).

  • The clinical trial from which the tumor specimens used in this study were derived showed improvements in relapse-free survival, locoregional control, and overall survival for those patients randomized to combined modality therapy [ 31 ] . This investigation established that patients whose tumors had M6P/IGF2R loss of heterozygosity and were treated with radiotherapy alone had a significantly worse prognosis than their counterparts with a non-mutated allele.

  • Loss of heterozygosity in cancer can occur either because of chromosomal deletion or somatic recombination resulting in uniparental disomy [ 37 ] . Comparative genomic hybridization studies in head and neck cancer [ 10 38 ] demonstrate that 6q deletion frequency (> 50%) is similar to that which we observed at the M6P/IGF2R locus.

  • CIS, carcinoma in situ ; HCC, hepatocellular carcinoma; IGF2, insulin-like growth factor 2; LOH, loss of heterozygosity; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; TGFβ, transforming growth factor beta; UTR, untranslated region.

  • Heterozygosity estimates of the Set 10 (and many Set 12) STRPs are also available from genotyping of the Human Diversity Panel [see Marshfield web site and reference [ 27 ] ].


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