Words similar to heteromeric
Example sentences for: heteromeric
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If the higher molecular weight band does represent a dimer of subunits, the heteromeric VR1/Δ2-52 ought to be intermediate in size between the homomeric dimers.
NMDA receptors are heteromeric ion channels composed of one NR1 subunit with combination of other NR2 subunits [ 4, 5, 6, 7].
Two splice variants of an A subunit (long and short forms), and a single B subunit have been cloned [ 10 11 12 13 ] . Both the long and short forms of the A subunit are capable of forming functional homomeric receptors [5-HT 3AL R and 5-HT 3AS R] although some differences between an agonist and partial agonist activity have been observed [ 14 ] . A third subtype is formed by a combination of the A and B subunits to produce a heteromeric receptor of unknown stoichiometry [ 10 ] . Heteromeric receptors are pharmacologically and functionally distinct from the homomeric 5-HT 3AL and 5-HT 3AS receptors [ 11 ] .
TGFβ signals through a heteromeric receptor complex of type II and type I receptor serine-threonine kinases, which activates the downstream Smad signal transduction pathway [ 7 ] . After TGFβ binding to the receptor complex, the TGFβ type II receptor kinase phosphorylates TGFβ type I receptor which inititates the downstream response by phosphorylating receptor-regulated Smads (R-Smads), such as Smad2 and Smad3.
For those ion channels within this superfamily for which stoichiometry has been directly examined, all have been shown to be composed of four six-transmembrane domain subunits or pseudosubunits, with auxiliary subunits sometimes present as well [ 22 ] . An initial characterization of VR1 channels expressed in Cos and CHO cells has recently revealed that, under certain conditions, they run as multimers on pseudo-native (PFO) gels, with tetramers being one of the primary bands observed [ 23 ] . Thus, like other six membrane spanning domain channels, VR1 almost certainly forms as a tetramer; whether it combines with homologous subunits to form heteromeric channels remains to be determined.
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