Words similar to heteromeric
Example sentences for: heteromeric
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In most cells, unliganded glucocorticoid receptors (GR) reside predominately in the cytoplasm, where they exist as a heteromeric complex comprised minimally of GR, 90-kDa and 70-kDa heat shock proteins (hsp90 and hsp70).
Overall, these data are consistent with previous reports that endocrine cells express voltage-sensitive ion channels that can contribute to the regulation of not only resting membrane potential and cell volume, but also cell proliferation and steroidogenesis [ 12 13 16 18 21 28 29 30 31 32 33 34 35 36 37 ] . The K +currents blocked by 4-AP in pig GC are conducted by ion channels formed by heteromeric complexes of pore-forming subunits from the KCNA (also called Kv1 or Shaker) family of proteins and accessory subunits from the KCNAB (also called Kvβ) family of proteins [ 4 ] . Similar 4-AP-sensitive K +currents play a key role in transduction of mitogenic signals in a variety of cell types, and 4-AP treatment has been associated with not only growth arrest but also apoptosis [ 2 3 8 9 10 14 38 39 40 41 42 ] .
Two splice variants of an A subunit (long and short forms), and a single B subunit have been cloned [ 10 11 12 13 ] . Both the long and short forms of the A subunit are capable of forming functional homomeric receptors [5-HT 3AL R and 5-HT 3AS R] although some differences between an agonist and partial agonist activity have been observed [ 14 ] . A third subtype is formed by a combination of the A and B subunits to produce a heteromeric receptor of unknown stoichiometry [ 10 ] . Heteromeric receptors are pharmacologically and functionally distinct from the homomeric 5-HT 3AL and 5-HT 3AS receptors [ 11 ] .
NMDA receptors are heteromeric ion channels composed of one NR1 subunit with combination of other NR2 subunits [ 4, 5, 6, 7].
When coexpressed with VR1, heteromeric channels composed of both types of subunits are expected to form.
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