Words similar to heterologously
Example sentences for: heterologously
How can you use “heterologously” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this case, it must be assumed that under control conditions (cells heterologously expressing only the receptors), mGluRs associate with natively-expressed CaM.
When Siah1a is caused to express heterologously (at presumably high levels) it expresses at levels high enough to out-compete native CaM for mGluR binding.
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
To assess the role of Siah1a binding, specific group I mGluRs were heterologously expressed in sympathetic neurons from the rat superior cervical ganglion (SCG), which do not natively express mGluRs [ 37 38 ] . The functional role of Siah1a was assessed by examining calcium current inhibition mediated by the expressed mGluRs in the absence and presence of heterologous Siah1a expression.
4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.
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