Words similar to heterodimer
Example sentences for: heterodimer
How can you use “heterodimer” in a sentence? Here are some example sentences to help you improve your vocabulary:
Despite the fact that p51 shares an identical amino acid sequence with the N-terminal portion of p66, the two subunits assume different global folding patterns in the formation of the asymmetric heterodimer [ 9 ] . Structural determination through X-ray crystallography has revealed that the p66 subunit of HIV-1RT has its polymerase domain in an "open" conformation, with its subdomains forming a large cleft which accommodates DNA.
Assembly of chimeric heterodimers formed by mixing subunits of HIV-1 RT and FIV-1 RT, has demonstrated that the p51 subunit of HIV-1 RT helps to preserve the functional integrity of the HIV-1 RT heterodimer [ 18 ] . Despite the fact that several functions have been proposed for the p51 subunit, the mechanism whereby p51 performs these functions has remained largely undefined.
We have therefore determined the structure of a heterodimer with a native interface.
It will be interesting to determine whether Asw homodimers display any binding to Hint substrates, what degree of Hint enzyme activity is retained by the putative Hint-Asw heterodimer, and whether Gln127 is required for depression of Hint enzymatic activity in Hint-Asw heterodimers.
This analysis suggested: first, that Hint and Asw do retain sufficient sequence identity at the dimer interface to form a heterodimer; second, that Asw has an insertion sequence at the bottom of the dimer that could be a site of alternative localization or proteolysis; and third, that Gln127, a residue that Asw has substituted for Trp123 of Hint, may interfere with the function of His114 in Hint across the dimer interface.
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