Words similar to heterodimeric

Example sentences for: heterodimeric

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Preparation of the heterodimeric enzyme with subunit specific insertion
However, many of the defects caused by gp130 loss are shared by mice with a null mutation of LIFR, reflecting the heterodimeric relationship of LIFR and gp130 for functional LIFR:gp130 signaling.
In the transmembrane region, although there is ample evidence for heterodimeric transmembrane domain association (Adair and Yeager 2002; Schneider and Engelman 2003; Gottschalk and Kessler 2004; Luo et al.
Cys→Ser mutation at position 280 in the p51 subunit has been shown to alter the RNase H activity of the heterodimeric enzyme, indicating that this residue in the thumb subdomain of p51 plays an important role in support of the RNase H activity of p66 [ 22 ] . The emergence of a strain of HIV-1 resistant to the non-nucleoside RT inhibitor TSAO (Tertbutyldimethyl silyspiro amino oxathioledioside) displaying Glu→Lys mutation at position 138 in the p51 subunit of HIV-1 RT has also been reported [ 23 ] , thus implicating p51 to play a more direct role in drug binding and/or the enzymatic activities of HIV-1RT.
These results suggest that insertion of six residues in the β7-β8 loop of p51 but not in p66 is detrimental to the function of the heterodimeric enzyme.