Words similar to heteroclitic

Example sentences for: heteroclitic

How can you use “heteroclitic” in a sentence? Here are some example sentences to help you improve your vocabulary:

Consequently, heteroclitic peptide analogs are predicted to be more immunogenic than their native counterparts because of more stable binding at the surface of antigen-presenting cells (APCs).
Thus, manipulating the immune T cell repertoire in vivo through the use of heteroclitic tumor antigen peptide variants could be harder than anticipated.
In contrast to the differences in RE for G209n peptide, similar assays revealed little difference in RE of the two clones for G209–2M heteroclitic peptide (Figure 4C), suggesting that these clones recognize the native and heteroclitic peptides differently, and that RE for the native, but not heteroclitic, peptide correlates with tumor-lytic potential.
While endogenous anti-tumor CD8+ T cell responses may already exist in some cancer patients [2], vaccination with TAA-derived peptides, and in particular heteroclitic peptide analogs, increases the frequency of TAA-specific T cell responses to detectable levels in many patients [3,4,5,6,7,8,9].
In summary, we have demonstrated that vaccination with heteroclitic peptide at high concentrations may drive T cell responses of variable tumor-cytolytic potential in cancer patients—and that the ability to lyse tumor cells correlates with the T cell's RE for native peptides.