Words similar to heteroclitic
- het
- hetauda
- hetero-compound
- heterochromatic
- heterochromatically
- heterochromatin
- heterochromatin-binding
- heterochromatin-derived
- heterochromatin-euchromatin
- heteroclitic
- heterocomplex
- heterocoupling
- heterocycle
- heterocycles
- heterocyst
- heterodera
- heteroderidae
- heterodimer
- heterodimerization
- heterodimers
Example sentences for: heteroclitic
How can you use “heteroclitic” in a sentence? Here are some example sentences to help you improve your vocabulary:
In contrast to the differences in RE for G209n peptide, similar assays revealed little difference in RE of the two clones for G209–2M heteroclitic peptide (Figure 4C), suggesting that these clones recognize the native and heteroclitic peptides differently, and that RE for the native, but not heteroclitic, peptide correlates with tumor-lytic potential.
Thus, high doses of peptide and/or the higher levels of expression of heteroclitic peptide on APCs may induce and actively propagate predominantly T cells with RE too low for recognition of physiological levels of the native peptide present on tumor targets.
In summary, we have demonstrated that vaccination with heteroclitic peptide at high concentrations may drive T cell responses of variable tumor-cytolytic potential in cancer patients—and that the ability to lyse tumor cells correlates with the T cell's RE for native peptides.
To address this important issue, we undertook a systematic examination of the complexity of T cell responses induced by heteroclitic peptide vaccination, and compared these responses to endogenous anti-tumor T cell responses which develop in some patients.
In recent cancer vaccine trials [3,4,5], many melanoma patients who received heteroclitic peptide vaccines gp100 209–217 (210M) (IMDQVPSFV; G209–2M) and MART 26–35 (27L) (ELAGIGILTV; M26) had measurable CD8+ peptide-specific T cell responses in PBMCs detected by peptide–MHC tetramer staining.
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