Example sentences for: differentiation

How can you use “differentiation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thymocytes in the adult Rag1 -/-thymus have been previously shown to have overall lower levels of proliferation than adult wild type TN thymocytes [ 13 ] , particularly at the TN3 stage [ 37 38 39 40 ] . At fetal stages, our results showed that proliferation also varied between thymocytes in the wild type and Rag1 -/-thymus at discrete stages of thymocyte differentiation.

  • There were no obvious differences in marker and gene-expression profile or in differentiation behavior among the five hESMPC lines generated.

  • Cells were plated in 24-well plates at a density of 10 6 cells per well, allowed to adhere for 4 h, then washed with Dulbecco's Modified Eagles Medium and further cultured in 10% FBS in Dulbecco's Modified Eagles Medium supplemented with 5 ng/ml GM-CSF (Sigma, St. Louis, Missouri, United States) to promote macrophage differentiation.

  • The following results of this study suggest that HIV-1 expression leads to cyclin D 1 -mediated G 1 → S progression in infected podocytes: cyclin D 1 transcript and protein levels are markedly up-regulated, phospho-Rb (Ser780) levels are increased, cyclin D 1 protein and phospho-Rb (Ser780) levels do not decrease with podocyte cell-cell contact and differentiation, and the up-regulation of cyclin D 1 requires the expression of HIV-1 genes, particularly HIV-1 nef.

  • Furthermore, recent studies demonstrated that Rb2/p130 in complexes with E2F-4 actively represses E2F-1 transcription in cell differentiation and growth arrest, and that this complex was considered the main E2F-1 regulator during the early G1 phase [ 39, 51, 52].


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