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Example sentences for: difficulty

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Finally, alignment of protein sequence to genomic DNA cannot predict untranslated regions (UTRs), and the leading ab initio gene prediction programs (Genscan [ 11], GlimmerM [ 12], Genemark.HMM [ 13]) have great difficulty predicting UTRs; most of them predict only the coding portion of a transcript.
One difficulty with interpreting such qualitative evidence, including Hox gene orthology, is that almost any pattern can be found in nature if one looks.
Numerous studies have shown that uninsured persons have greater difficulty accessing inpatient care, fewer procedures, and shorter hospitalizations, and are more likely to receive substandard care for medical injury.
We did not weight OSCE questions, stations or skills according to degree of difficulty.
CASP1 was an eye-opener in terms of understanding the difficulty of making accurate predictions on approximate templates in comparative modelling [ 14 ] . The main problems in creating a good comparative or fold recognition model were related to alignment between the template and target sequences, and building of non-conserved variable regions (side chains, and main chain loops).