Example sentences for: difficult-to-treat

How can you use “difficult-to-treat” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This, together with other studies, strongly suggests that BP1 has oncogenic properties, making it a new potential target in breast tumors, especially the difficult-to-treat ER-negative tumors.

  • Estrogen and progesterone, which stimulate the growth of breast epithelium, are two crucial hormones involved not only in normal breast development but also in carcinogenesis of breast epithelium and progression of breast cancer [ 28 ] . About 40% of breast cancers are ER-negative [ 28 ] . ER-negative tumors are unresponsive to anti-estrogen therapy, probably because of constitutive growth factor expression [ 28 29 ] . In general, these tumors have a higher histologic grade and a higher proliferative rate and are associated with poorer prognosis [ 28 ] . The finding that 100% of ER-negative tumors expressed BP1 might therefore be highly relevant to both the prognosis and therapy of those difficult-to-treat tumors.

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