Words similar to difficult

Example sentences for: difficult

How can you use “difficult” in a sentence? Here are some example sentences to help you improve your vocabulary:

A complication of this interpretation is that some members of gene families will cross-hybridize, making it difficult to resolve whether there are large numbers of organ-specific genes within such families.
As cooperativity is difficult to invoke in this system, we consider that for Asw to titrate Hint enzyme activity by heterodimerization, Asw must carry a signal for mislocalization and/or proteolysis, and/or somehow alter the Hint active site.
However, fluid management in patients with ARDS and septic shock can be difficult.
It is difficult to be amusing in praise of something.
Similarly, “interdisciplinary” can also mean “hard to find”—companies with targeted recruitment often miss PSM students, who are not “in” any particular department—and “confusing”—differences in these new, still somewhat vaguely defined programs can make hiring comparisons difficult.