Words similar to difficult

Example sentences for: difficult

How can you use “difficult” in a sentence? Here are some example sentences to help you improve your vocabulary:

But that opens another can of worms, and Lemann's stab at the enormously difficult problem of improving education at the lower levels is not too encouraging: "We should adopt the goal of sending most people all the way through college ...
Although anterior segment cloudiness often made ophthalmoscopy difficult in
( Open motor boats were also responsible for the vast majority of boat-related hospital admissions , with cabin motorboats ranking a distant second and canoes and kayaks ranking an even-more distant sixth; presumably if you get into a serious accident on a kayak or canoe, it's more difficult to get yourself to a hospital .)
This makes computational recognition of invertebrate promoters, and those vertebrate promoters not found in CpG islands, more difficult.
It is difficult to translate these results into the clinical setting due to the limited number of studies, focused anatomical sites and populations studied.