Words similar to difficult

Example sentences for: difficult

How can you use “difficult” in a sentence? Here are some example sentences to help you improve your vocabulary:

Because this mechanism presumably involves circulating antigen, it is difficult to invoke a role for X-inactivation skewing in altering this process, unless the skewing were virtually complete.
Thomas in the New York Times Book Review . "Whereas descriptions of human illness are inherently interesting, it is difficult for most readers to get as worked up about cycads and ferns as Sacks seems to be," says the Washington
Data such as those in Figure 9 are not readily available and would be difficult to develop.
The Academy's report also tells us that there are many unanswered questions about climate change, which makes it difficult to determine what levels of greenhouse gas emissions need to be avoided.
The number of new patients requiring therapy is relatively small, and the Genzyme Corporation has done little to encourage the performance of dose–response studies, making it difficult to enroll patients.