Example sentences for: differentiating

How can you use “differentiating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Previous studies compared CRP, IL-2, IL-6, and TNF-α and PCT separately for differentiating SIRS from sepsis; in the present study, all of the available biochemical markers were measured at the same time [ 4, 7, 8, 9, 10].

  • There are a number of striking similarities in the morphogenesis of hairs, laterals and bristles [ 8 ] . Data presented here for laterals and previously for wing hairs [ 10 ] show that the asymmetric accumulation of Fz is prominent in these terminally differentiating cells.

  • We also detected increased expression of Neurogenin3 (ngn3) (see Figure 1C), a transcription factor expressed in differentiating neurons, and required for development of pancreatic islet progenitor cells [24,25,26].

  • If the thymic dendritic cell population exhibits random X inactivation, it is highly likely that differentiating thymocytes will contact dendritic cells that express self-antigens on both X chromosomes.

  • In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [ 16 ] . Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [ 17 ] . Alpha-crystallin has also been shown to interact directly with DNA [ 18 ] . In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [ 19 ] . A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [ 20 ] . In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [ 21 ] . These findings indicate that alpha-crystallin may have a multitude of in vivo functions.


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