Example sentences for: differentiation-associated

How can you use “differentiation-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • With intrinsic factors, unequal amounts of cell-fate determinants are distributed into the two cells prior to their separation [ 29 ] . Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . Mammalian cells known to exhibit asymmetric division include diverse cell types such as neuronal cells, thymocytes, and satellite cells involved in myogenesis, and the list is growing [ 29 30 31 32 ] .

  • While the parental cell showed high nuclear ERα, the daughter cell associated with ST showed marked diminution of ERα immunoreactivity and an increase of differentiation-associated ERβ protein.

  • These observations parallel recent studies that postmitotic cells may exhibit asymmetric distribution of the differentiation-associated proteins prior to their separation.

  • Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . When the neuronal progenitor cells undergo asymmetric division (20% in neuronal tissue cell culture) they produce neuronal daughter cells to which Numb protein segregates preferentially, and such daughter cells show an enhanced differentiation of neuronal processes [ 45 ] . Interestingly, Numb is firstly associated with one pole of the plasma membrane of a dividing cell, and subsequently with one of the two resulting nuclei [ 29 45 ] . Our study indicates that preservation of nuclear ERα in one of two postmitotic cells is associated with the ability of CT to replicate and diminution of ERα and appearance of nuclear ERβ dictates a generation of a daughter cell that is committed to differentiate (Fig.


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